Posts Tagged ‘ Bioinformatics ’

The avalanche of publications mentioning GO

November 30, 2010
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The avalanche of publications mentioning GO

Gene Ontology is the de facto standard for annotation of gene products. It has been widely used in biological data mining, and I believe it will play more central role in the future. Publications mentioning GO was collected and deposited in GO ftp, and can be accessed (ftp://ftp.geneontology.org/go/doc/). Read More: 454 Words Totally

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GOSemSim redesign in terms of S4 classes

November 30, 2010
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I started to develop GOSemSim package two years ago when I was not quite familiar with R. I am very happy to see that someone use it and found it helpful. I try to learn S4 and redesign GOSemSim with S4 classes and methods in the pass two weeks, and the very first version was implemented. As I’m...

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Listing gene IDs from hyperGTest

October 19, 2010
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hyperGTest compute Hypergeomtric p-values for over or under-representation of each GO term in the specified category among the specified gene set. *geneSample* was used as an example. Read More: 1329 Words Totally

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Export R data to tex code

October 12, 2010
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Export R data to tex code

We often use Gnu R to work on different things and to solve various exercises. It's always a disgusting job to export e.g. a matrix with probabilities to a LaTeX document to send it to our supervisors, but Rumpel just gave me a little hint.

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ClusterProfiles

October 12, 2010
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ClusterProfiles

It is very common to cluster genes based on their expression profiles, and also very common to integrate Gene Ontology to observe the distribution of biological processes, molecular functions and cellular components for a given gene list. But, what if the two in combination? The Gene Ontology distributions across a variety of gene clusters may give us a...

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BioStar users (of the world, unite)

October 9, 2010
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BioStar users (of the world, unite)

Egon writes: Can someone please plot the BioStar users on a Google Map? Sounds like a challenge. Let’s go. 1. Harvesting user IP addresses BioStar user profiles (here’s mine) include a location field. It’s free text and optional, which means that location is missing or inaccurate for many users. However, if you’re logged into BioStar

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GEO database: curation lagging behind submission?

August 30, 2010
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GEO database: curation lagging behind submission?

I was reading an old post that describes GEOmetadb, a downloadable database containing metadata from the GEO database. We had a brief discussion in the comments about the growth in GSE records (user-submitted) versus GDS records (curated datasets) over time. Below, some quick and dirty R code to examine the issue, using the Bioconductor GEOmetadb

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Analysing the ISMB 2010 meeting using R

July 20, 2010
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Analysing the ISMB 2010 meeting using R

The colossus of bioinformatics meetings, ISMB, convened in Boston this year from July 9 – 13. As in recent years, the meeting was covered online at its website, FriendFeed and Twitter. I thought it would be fun to run a quick analysis of activity at the FriendFeed room using R. 1. Fetch the data We

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biomaRt and GenomeGraphs: a worked example

June 6, 2010
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biomaRt and GenomeGraphs: a worked example

As promised a few posts ago, another demonstration of the excellent biomaRt package, this time in conjunction with GenomeGraphs. Here’s what we’re going to do: Grab some public microarray data Normalise and get a list of the most differentially-expressed probesets Use biomaRt to fetch the genes associated with those probesets Plot the data using GenomeGraphs

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Top 10 Algorithms in Data Mining

April 23, 2010
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The authors here invited ACM KDD Innovation Award and IEEE ICDM Research Contributions Award winners to each nominate up to 10 best-known algorithms in data mining, including the algorithm name, justification for nomination, and a representative public...

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