Articles by Keith Goldfeld

To stratify or not? It might not actually matter…

May 11, 2020 | Keith Goldfeld

Continuing with the theme of exploring small issues that come up in trial design, I recently used simulation to assess the impact of stratifying (or not) in the context of a multi-site Covid-19 trial with a binary outcome. The investigators are concerned that baseline health status will affect the probability ...
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Can unbalanced randomization improve power?

March 30, 2020 | Keith Goldfeld

Of course, we’re all thinking about one thing these days, so it seems particularly inconsequential to be writing about anything that doesn’t contribute to solving or addressing in some meaningful way this pandemic crisis. But, I find that working provides a balm from reading and hearing all day ...
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Clustered randomized trials and the design effect

February 17, 2020 | Keith Goldfeld

I am always saying that simulation can help illuminate interesting statistical concepts or ideas. The design effect that underlies much of clustered analysis is could benefit from a little exploration through simulation. I’ve written about clustered-related methods so much on this blog that I won’t provide links - ...
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What can we really expect to learn from a pilot study?

November 11, 2019 | Keith Goldfeld

I am involved with a very interesting project - the NIA IMPACT Collaboratory - where a primary goal is to fund a large group of pragmatic pilot studies to investigate promising interventions to improve health care and quality of life for people living with Alzheimer’s disease and related dementias. ...
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Selection bias, death, and dying

October 14, 2019 | Keith Goldfeld

I am collaborating with a number of folks who think a lot about palliative or supportive care for people who are facing end-stage disease, such as advanced dementia, cancer, COPD, or congestive heart failure. A major concern for this population (which really includes just about everyone at some point) is ...
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Simulating an open cohort stepped-wedge trial

September 16, 2019 | Keith Goldfeld

In a current multi-site study, we are using a stepped-wedge design to evaluate whether improved training and protocols can reduce prescriptions of anti-psychotic medication for home hospice care patients with advanced dementia. The study is officially called the Hospice Advanced Dementia Symptom Management and Quality of Life (HAS-QOL) Stepped Wedge ...
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