(This article was first published on

Apologies for the long and unannounced break-- the longest since we started blogging, three and a half years ago. I was writing a 2-day course for SAS users to learn R. Contact me if you're interested. And Nick and I are beginning work on the second edition of our book-- look for it in the fall. Please let us know if you have ideas about what we omitted last time or would otherwise like to see added. In the mean time, we'll keep blogging, though likely at a reduced rate. **SAS and R**, and kindly contributed to R-bloggers)Today: what can you say about the probability of an event if the observed number of events is 0? It turns out that the upper 95% CI for the probability is 3.69/N. There's a sweet little paper with some rationale for this, but it's in my other office. And I couldn't recall the precise value-- so I used SAS and R to demonstrate it to myself.

**R**

The R code is remarkably concise. After generating some Ns, we write a little function to perform the test and extract the (exact) upper 95% confidence limit. This is facilitated by the "..." notation, which passes along unused arguments to functions. Then we use

`apply()`to call the new function for each N, passing the numerator 0 each time. Note that

`apply()`needs a matrix argument, so the simple vector of Ns is converted to a matrix before use. [The

`sapply()`function will accept a vector input, but took about 8 times as long to run.] Finally, we plot the upper limit * N against N. showing the asymptote. A log scaled x-axis is useful here, and is achieved with the

`log='x'`option. (Section 5.3.12.) the result is shown above.

bin.m = seq(10, 10000, by=5)

mybt = function(...) { binom.test(...)$conf.int[2] }

uci = apply(as.matrix(bin.m), 1, mybt, x=0)

plot(y=bin.m * uci, x=bin.m, ylim=c(0,4), type="l",

lwd=5, col="red", cex=5, log='x',

ylab="Exact upper CI", xlab="Sample size",

main="Upper CI when there are 0 cases observed")

abline(h=3.69)

**SAS**

In SAS, the data, really just the N and a numerator of 0, are generated in a

`data`step. The CI are found using the

`binomial`option in the

`proc freq tables`statement and saved using the

`output`statement. Note that the

`weight`statement is used here to avoid having a row for each Bernoulli trial.

data binm;To calculate the upper limit*N, another

do n = 10 to 10000 by 5;

x=0;

output;

end;

run;

ods select none;

proc freq data=binm;

by n;

weight n;

tables x / binomial;

output out=bp binomial;

run;

ods select all;

`data`step is needed-- note that in this setting SAS will only produce the lower limit against the probability that all observations share the same value, thus the subtraction from 1 shown below. The log scale x-axis is obtained with the

`logbase`option to the

`axis`statement. (Section 5.3.12.) The result is shown below.

data uci;It's clear that the upper 95% limit on the number of successes asymptotes to about 3.69. Thus the upper limit on the binomial probability p is 3.69/N.

set bp;

limit = (1-xl_bin) * n;

run;

axis1 order = (0 to 4 by 1);

axis2 logbase=10 logstyle=expand;

symbol1 i = j v = none c = red w=5 l=1;

proc gplot data=uci;

plot limit * n / vref=3.69 vaxis=axis1 haxis=axis2;

label n="Sample size" limit="Exact upper CI";

run;

quit;

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