Continuing from last week, I will now look at incidence rates of measles in the US. To recap, Project Tycho contains data from all weekly notifiable disease reports for the United States dating back to 1888. These data are freely available to any...

Chapter 19 of Rowland and Tozer (Clinical pharmacokinetics and pharmacodynamics, 4th edition) has distribution kinetics. I am examining problem 3. It is fairly easy, especially since essentially all formulas are on the same page under 'key relationships'. The only difficulty is that the formulas are symmetrical in λ1, c1 and λ2, c2 and they are exchanged between chains. For this...

In this third PK posting I move to chapter 10, study problem 4 of Rowland and Tozer (Clinical pharmacokinetics and pharmacodynamics, 4th edition). In this problem one subject gets a 24 hours continuous dose. In many respects the Jags calculation is not very different from before, but the relation between parameters in the model and PK parameters is a...

In this post I want to analyze a first order pharmocokinetcs problem: the data of study problem 9, chapter 3 of Rowland and Tozer (Clinical pharmacokinetics and pharmacodynamics, 4th edition) with Jags. It is a surprising simple set of data, but still there is enough to play around with.Data, model and analysisThe data is simple enough. One subject's concentration...