I use R and Bioconductor for most of my work. I am also increasingly replacing things I would have done before in Perl with R. One such example of this is the Bioconductor module biomaRt.
As the name suggest it allows for access to BioMart via R. BioMart is a method of accessing large online databases...


Zero Inflated Models and Generalized Linear Mixed Models with R.
Zuur, Saveliev, Ieno (2012).