**Computational Biology Blog in fasta format**, and kindly contributed to R-bloggers)

Say that you are implementing a non-linear regression analysis, which is shortly described by wikipedia as:

“In statistics, nonlinear regression is a form of regression analysis in which observational data are modeled by a function which is a nonlinear combination of the model parameters and depends on one or more independent variables.”

For the training set, we have the following:

And the function to optimize the parameters is:

Which leads us to the following equality:

In other words, we want to optimize the value of theta in order to minimize the sum of the error among y and predicted.y:

Given theta (each parameter a0,..a3 has a range from 0 to 15):

And the error function:

finally, the goal function:

In other words, the goal function searches for the value of theta that minimizes the error.

COMPUTATIONS BEGIN

This is the scatter plot of the training set:

Here is the implementation in R, you can download the file clicking here

Here is a result plot using the genetic algorithm:

Benjamin

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**Computational Biology Blog in fasta format**.

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